These are issues connected only to the "Speedy Blupi" games, not "Speedy Eggbert" games.
Speedy Blupi game requires CD-ROM
Open the file{install dir}/DATA/Config.def with a text editor (like notepad, for example).
Change line like CD-Rom=V:\US
to CD-Rom=-nocd
Note: Speedy Eggbert does not have these CD-ROM check.s